摘要: |
目的:观察A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床效果。方法:选取33例三叉神经痛或带状疱疹后神经痛患者,进行疼痛区域A型肉毒毒素皮下或皮内注射治疗,评估患者治疗时、治疗2周后、治疗3个月后疼痛情况(NRS)、睡眠状况及生活质量(QOL),判断治疗效果,观察药物不良反应。结果:患者使用A型肉毒毒素治疗2周后、3个月后疼痛评分、睡眠评分显著低于治疗时(P<0.05),生活质量显著高于治疗时(P<0.05),治疗效果好,不良反应少。结论:A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛效果显著,可成为神经病理性疼痛治疗的一种新途径。 |
关键词: A型肉毒毒素 三叉神经痛 带状疱疹后神经痛 |
DOI:10.12025/j.issn.1008-6358.2020.20200752 |
分类号:R745.1+1 |
基金项目: |
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Clinical study on the treatment of trigeminal neuralgia and post-herpetic neuralgia with botulinum toxin type A |
LI Hua-liang, PAN Ping-lei, CHEN Jia-hui, LUO Rong, SHEN Yuan, ZHONG Jian-guo
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Department of Neurology, the Third People's Hospital of Yancheng, Yancheng 224005, Jiangsu, China
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Abstract: |
Objective: To observe the clinical effect of botulinum toxin type A (BTX-A) on trigeminal neuralgia (TN) and post-herpetic neuralgia (PHN). Methods: Thirty-three patients with TN or PHN were treated by subcutaneous or intradermal injection of BTX-A into the pain area, the patients' numerical rating scale (NRS), sleep status and quality of life (QOL) at the time of treatment, 2 weeks after treatment, and 3 months after treatment were evaluated, the treatment effect and the drug adverse reactions were analyzed. Results: After 2 weeks and 3 months of treatment with BTX- A, NRS and sleep score of the patients were significantly lower than those at the time of treatment (P<0.05), QOL was significantly higher than that at the time of treatment (P<0.05). Treatment effect was good and few side effects were observed. Conclusions: BTX-A is effective in treating TN and PHN and can become a new therapeutic approach for neuropathic pain. |
Key words: botulinum toxin-A trigeminal neuralgia post-herpetic neuralgia |