摘要: |
目的:检测绝经后妇女患者血清25-羟维生素D[25-(OH)D]水平变化,观察其与冠心病发病率的关系。方法:使用横断面研究的方法,以我院体检中心体检的人群取样,采用化学发光法检测200例绝经后妇女外周血血清25-(OH)D,结合体检结果使用统计学分析维生素D与冠心病发病率及其危险因素之间的关系。结果:绝经后妇女血清25-(OH)D 水平为23.3±8.8ng/ml,缺乏率为71%和不足率为18%,正常率仅11%,三组之间冠心病的发病率分别为28.9%、11.1%和4.5%,三组比较差异有统计学意义;绝经后妇女人中血清25-(OH)D水平与在不同的高密度脂蛋白、低密度脂蛋白和BMI指数分组中表达具有显著性差异。结论:绝经后妇女血清25(OH)D水平明显低下,缺乏程度与冠心病发病率相关。 |
关键词: 冠心病 25-羟维生素D 绝经 |
DOI:10.12025/j.issn.1008-6358.2017.20160765 |
分类号: |
基金项目:南平市级课题 编号:N2014D012 |
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Research on women"s vitamin D levels and the incidence of coronary heart disease in postmenopausal women Jiang Lin SHEN Xuebin Ye Guiyun CHEN Sheng HUANG Qilei Second Department of Cardiology/ Clinical Laboratory, Nan Ping First Affiliated Hospital, Fujian Medical University, Fujian 353000, China |
Jiangling,Shen Xuebin,Ye Guiyun,Chen Sheng and Huang Qilei
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Second Department of Cardiology, Nan Ping First Affiliated Hospital, Fujian Medical University,Second Department of Cardiology, Nan Ping First Affiliated Hospital, Fujian Medical University,Clinical Laboratory, Nan Ping First Affiliated Hospital, Fujian Medical University,Second Department of Cardiology, Nan Ping First Affiliated Hospital, Fujian Medical University,Second Department of Cardiology, Nan Ping First Affiliated Hospital, Fujian Medical University
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Abstract: |
Objective: Indentify the level of serum 25-hydroxyvitamin detected D [25- (OH) D] in postmenopausal women and relationship with coronary heart disease. Methods: We use cross-sectional study to take samples from health examination center, applying electrochemi-luminescence methods to test 25- (OH) D in 200 cases of postmenopausal women. Coronary heart disease (CHD) incidence, its risk factors and level of 25-(OH)D were analyzed by statistical method. Results: Serum 25-(OH)D levels of women after menopause was 23.3 ± 8.8ng/ml. 71% of population was defined as deficiency, 18% insufficiency and 11% desirable range. The incidence of CHD among the three groups, was 28.9%, 11.1% and 4.5% respectively. The difference was statistically significant. Serum 25-(OH) D levels expression were significant differents in varying degrees of high-density lipoprotein, low-density lipoprotein and body mass index. Conclusion: Postmenopausal women have significantly lower serum 25 -(OH) D levels, the degree of deficiency correlates with CHD incidence. |
Key words: coronary heart disease 25-hydroxy vitamin D menopause |