Prognosis of fundus hemorrhage after PDT combined anti-VEGF treatment in polypoidal choroidal vasculopathy patients

Objective： To observe the retinal images and therapic results of fundus hemorrhage after PDT combined anti-VEGF treatment in polypoidal choroidal vasculopathy patients. Methods： Retrospective analysis were used to analyze the clinic history and signs of 5 cases with diagnosed PCV patients which fundus hemorrhage were found after PDT combined anti-VEGF therapy between March 2010 to March 2015. Medical examination such as visual acuity, angiography were also involved during 3-24 monthes. Results： Among 5 partients, 2 patients suffered from subretinal hemorrhage between 1 week to 1 month after combination therapy; 1 patients suffered from vitreous hemorrhage in 1 week after anti-VEGF injection; 2 patients suffered subretinal hemorrhage within 1 month after the second PDT therapy. 4 patients of above was treated successfully by medical treatment and most of the hemorrhage was absorbed and their visual acuity were rescued to 0.2 on average; last patient with huge vitreous hemorrhage was received pars plana vitrectomy surgery for hemorrhage treatment. Conclusions： Hemorrhage risks were possible in combination therapy using PDT and anti-VEGF to PCV patients. The mechanism may associated to changes of hemodynamics after therapy or blood vessel brittleness increases in lesion area, which needs further research to clarify.