Clinical phenotypic characteristics of patients with Parkinson disease with suspicious rapid eye movement sleep behavior disorder

Objective：To investigate the clinical phenotypic characteristics of patients with Parkinson disease (PD) with suspicious rapid eye movement sleep behavior disorder (cpRBD) and its related factors. Methods：The German version of the RBD screening scale (RBDSQ) and related neuropsychological assessment scales were used to investigate the incidence of cpRBD in 110 Chinese patients with PD. The association between the incidence of cpRBD and demographic data, motor symptoms, non-motor symptoms (hyposmia, depression, constipation, autonomic and cognitive function assessment, etc), and major motor complications (wearing-off and dyskinesia) were analyzed. Results：A total of 40 PD patients were complicated with cpRBD, accounting for 36.4%. Compared with PD patients without cpRBD, PD patients with cpRBD had higher scores in the non-motor symptoms questionnaire (NMSQ) and the scale for outcomes in PD for autonomic symptoms (SCOPA-AUT), and higher proportions of males, hyposmia, constipation, and depressive symptoms (P<0.05). There was no statistical difference regarding the severity of motor symptoms, the subtype of motor symptoms, and the proportion of major motor complications between the two groups. Multivariate logistic regression analysis showed that male (OR=3.541, 95%CI 1.269-9.877, P=0.016), depressive symptoms (OR=5.365, 95%CI 1.161-11.470, P=0.027), and high SCOPA-AUT score (OR=1.098, 95%CI 1.005-1.200, P=0.038) were independent factors for cpRBD in PD patients. Conclusions：PD patients with cpRBD are more common in males, and those with more serious non-motor symptoms, depression and severe autonomic dysfunction may increase the occurrence of RBD in PD patients.