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CHEN Shi-yu, JIANG Long, CANG Jing, et al. Nalmefene suppresses fentanyl-induced cough during general anesthesia induction: a randomized, double-blind, controlled trial[J]. Chin J Clin Med, 2019, 26(2): 265-267.
Citation: CHEN Shi-yu, JIANG Long, CANG Jing, et al. Nalmefene suppresses fentanyl-induced cough during general anesthesia induction: a randomized, double-blind, controlled trial[J]. Chin J Clin Med, 2019, 26(2): 265-267.

Nalmefene suppresses fentanyl-induced cough during general anesthesia induction: a randomized, double-blind, controlled trial

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  • Objective:To evaluate the suppressive effects of nalmefene pretreatment on the incidence of fentanyl-induced cough (FIC), and to observe the influence of nalmefene pretreatment on hemodynamic stability during general anesthesia induction. Methods:A total of 78 patients of American Society of Anesthesiologists(ASA)Ⅰand Ⅱ were enrolled and randomly divided into 3 groups (26 patients in each group). Patients in the 3 groups were ventilated by face mask 2 min (T0) after entering the operating room. Patients in the control group,nalmefene 0.25 group, nalmefene 0.5 group received normal saline, 0.25 μg/kg nalmefene,or 0.5 μg/kg nalmefene 10 mL before anesthesia induction respectively,2 min later(T1), the heart rate (HR), noninvasive blood pressure (NBP), and pulse oxygen saturation(SpO2) were recorded. Patients were then administrated with 4 μg/kg fentanyl within 5 s. The incidence of FIC and the vital signs were recorded 2 min after administration of fentanyl bolus (T2). After T2, patients were administered with 2.5 mg/kg propofol, 0.6 mg/kg rocuronium, and 1.5 mg/kg lidocaine, 90 s later, the intubation was performed (T3). The vital signs were also recorded after T3. Results:The incidence of cough in the control group was 53.8%, much higher than that in the nalmefene 0.25 group (3.8%,P<0.01) and nalmefene 0.5 group(0%, P<0.01). There was no significant difference in the hemodynamics between the control group and the nalmefene groups in the corresponding time points. Conclusions:Pretreatment of nalmefene could effectively suppress the FIC during general anesthesia induction, and it might not reverse the effect of opioids on sympathetic response and influencethe hemodynamic stability.
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