Long-chain non-coding RNA-linc00152 expression may play a role in apoptosis and migration of vascular endothelial cells via miR-4767

Objective：To explore the role of long-chain non-coding RNA (lncRNA)-linc00152 in the apoptosis and migration of vascular endothelial cells (VECs) and the underlying mechanisms. Methods：Human umbilical vein endothelial cell (HUVEC) were treated with oxidized-low density lipoprotein (ox-LDL) which was solving in fetal bovine serum (FBS). The interactions of linc00152 and miR-4767 in HUVEC were detected by transfection of vectors, Western blotting, luciferase construction, and biotinylation analysis. Then the effects of miR-4767 and linc00152 on the apoptosis and migration of HUVEC and the underlying mechanisms were explored. Results：The expression of miR-4767 was negatively regulated by linc00152 (P<0.05). miR-4767 increased the apoptosis of HUVEC and decreased their migration; linc00152 decreased the apoptosis of HUVEC and increased their migration (P<0.05). After blocking miR-4767, the apoptosis and migration induced by linc00152 knockdown were reduced, meanwhile, the decrease of Bc12L12 and epidermal growth factor receptor (EGFR) induced by linc00152 knockdown were attenuated. Conclusions：Linc00152 may become a potential therapeutic target for improving vascular endothelial function and treating some cardiovascular diseases.