Comparison of the radiation dose and perfusion parameters of whole liver computed tomography perfusion with different generations of 320-detector computed tomography

Objective：To retrospectively analyze the differences of radiation dose and perfusion parameters of whole liver computed tomography (CT) perfusion using the first and second-generation 320-detector CT machine. Methods：Imaging data of 78 randomly enrolled patients who underwent whole liver CT perfusion were analyzed. Among which, 42 patients (group A) were examined with the first-generation 320-detector CT, while 36 patients (group B) were examined with the second-generation CT. The CT perfusion parameters of normal liver tissue including the hepatic arterial flow (HAF), the portal venous flow (PVF), the perfusion index (PI) were compared between the two groups. And the radiation dose parameters including the volume CT dose index (CTDI), the dose length product (DLP), and the effective radiation dose (ED) were compared between the two groups. Results：No significant difference in the perfusion parameters (HAF, PVF, and PI) was found between the two groups. The radiation dose (CTD, DLP, and ED) in group B reduced obviously than that in group A (P<0.01). Conclusions：The second-generation 320-detector CT has reduced radiation dose for the whole liver CT perfusion, and does not significantly affect the perfusion parameters.