Research progress on pathogenesis of chronic gouty tophus

Gouty tophus contributed to joint activity limitation and deformation in patients. The urate solubility, concentration of ions, connective tissue proteins, and neutrophil extracellular traps factors all have relationship with the nucleation and growth of monosodium urate(MSU) crystal, among which, the increase of urate concentration is the only identified factor for the MSU crystallization.