Reserch progresses on the pathophysiology and treatment strategies of cirrhotic cardiomyopathy

Cirrhotic cardiomyopathy(CCM) is one of the common complications of cirrhosis .Due to CCM remains asymptomatic in the resting state, it becomes overt heart failure only under stress, and has not be paid more attention. It is characterized by impaired contractile responsiveness to stress, altered diastolic relaxation, electrophysiological abnormalities(especially QTc interval prolongation). At present, the pathogenesis of CCM is unknown, and doesn’t have specific treatment measures.Compared with heart failure caused by other diseases,drug treatment efficacy has limitations.Most of the studies have proved that orthotopic liver transplantation,as the eventual treatment for end-stage liver diseases,may reverse cardiac dysfunction. However,the cardiac function before transplantation should be evaluated.It is crucial to develop more accurate diagnostic tools and effective treatment strategies.This review discusses the advances in the pathophysiology and treatment strategies of CCM.