The potential role of forkhead box O3 mediated Th1/Th17/Treg imbalance in the pathogenesis of Behçet's syndrome

Behçet's syndrome (BS) is a chronic recurrent variant vasculitis involving multiple important organs. The immune disorder is the basis of occurrence and development of BS, and the imbalance of T helper cell (Th) 1/Th17/regulatory T cell (Treg) plays an important role. Forkhead box O3 (FOXO3) can modulate the activation, differentiation, and function of T cells. The change of FOXO3 expression is related to the imbalance of Th1/Th17/Treg, which makes FOXO3 a potential target for the treatment of immune diseases. At present, there is few research on FOXO3 and BS, so this paper summarizes and looks forward to the mechanism of FOXO3 as a potential therapeutic target for BS.