Predictive value of IL-8 combined with the sequential organ failure score for uroseptic shock without urological surgery

Objective To explore the predictive value of risk factors combined with the sequential organ failure assessment (SOFA) for uroseptic shock without urological surgery.

Methods The clinical data and cytokines levels of 57 patients with urosepsis without urologic surgery admitted to Zhongshan Hospital, Fudan University from March 2018 to May 2021 were retrospectively collected. They were divided into shock group and non-shock group according to whether shock occurred, and the clinical characteristics of patients in two groups were compared. The risk factors of uroseptic shock without urological surgery were analyzed by the binary logistic regression analysis, and the efficacy of each parameter in predicting the disease was analyzed by the receiver operating characteristic curve.

Results Compared with the non-shock group, patients in the shock group had higher SOFA scores and female ratio at admission, multiple organ dysfunction syndrome incidence, and levels of interleukin-1β (IL-1β), IL-8, and IL-10. After adjusting for gender, high level of IL-8 (≥48 pg/mL) was an independent risk factor for uroseptic shock without urological surgery(OR＝3.579, 95%CI 1.084-11.813, P＝0.036), and it combined with SOFA scores was the most effective predictor of the disease (AUC＝0.818, 95%CI 0.707-0.928, P < 0.001).

Conclusion SOFA score combined with high level of IL-8 (≥48 pg/mL) had a good predictive effect on the disease, which was of clinical value for early diagnosis and treatment of the disease.