Objective To explore the correlation of serum complement C1q level and the degree of coronary stenosis and heart failure after myocardial infarction during 1 year after discharge.
Methods A total of 162 patients with acute myocardial infarction admitted in Changhai Hospital, Naval Medical University from March 2020 to March 2021 were selected. The plasma complement C1q within 24 h was detected, and patients were divided into three groups according to the level of complement C1q with 54 patients in each group. Baseline data and cardiac function were compared among 3 groups. The follow-up was took to observed whether patients had heart failure within 1 year after discharge. The receiver operating characteristic curve (ROC) was used to analyzed the predictive value of complement C1q to heart failure following acute myocardial infarction.
Results There was statistically significant difference in heart failure rate after discharge among the three groups (P＝0.004). With a median follow-up time of 12 months, a total of 36 patients developed heart failure after myocardial infarction. C1q level was significantly lower in patients with heart failure 1 year after discharge than in those without heart failure (158.46±33.59 mg/L vs 180.38±34.92 mg/L, t＝3.35, P＝0.001). Logistic multivariate analysis suggested that low C1q level was an independent risk factor for heart failure following myocardial infarction (OR＝4.223, 95% CI 1.249-14.274, P＝0.02).The area under the ROC curve (AUC) of C1q prediting heart failure was 0.703 (95%CI 0.627-0.772). The predicted sensitivity was 41.67% and the specificity was 92.86% with a cut-off value of 138.2 mg/L.
Conclusions The lower serum C1q level early after myocardial infarction, the greater the probability of heart failure after discharge.
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