Analysis of risk factors associated with the degree of premature coronary heart disease in women

Objective To analyze the relationship between the severity of coronary artery disease and risk factors related to coronary heart disease (CHD) in women with premature CHD.

Methods A total of 212 female patients with premature CHD aged < 65 years confirmed by coronary angiography from January 2017 to April 2020 were included. The coronary lesions of the patients were evaluated by Gensini score. According to the score, the patients were divided into mild lesion group (n=67), moderate lesion group (n=70), and severe lesion group (n=75). The risk factors among each group were compared, and the relationship between the risk factors and Gensini score was analyzed.

Results There were significant differences in high-density lipoprotein cholesterol (HDL-C), non-HDL-C, apolipoprotein B, and blood uric acid among 3 groups (P < 0.05). Multiple linear regression analysis showed that HbA₁c and uric acid levels had positive impacts on Ginsini score, with B values of 3.571 and 0.08 (P < 0.01).

Conclusions The levels of HbA₁c and uric acid have positive impacts on the degree of coronary lesions in women with premature CHD.