Research progress of NLRP3 inflammasome as a potential therapeutic target for kidney disease

Plenty of evidence suggested an association between kidney disease and inflammasomes, especially nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasomes. NLRP3 inflammasomes play an important role in renal inflammation and fibrosis. Small molecule inhibitors targeting the components of NLRP3 inflammasomes are potential options for the treatment of kidney-related diseases. This article reviews the new findings of the role of NLRP3 inflammasomes in kidney disease in recent years and new strategies targeting NLRP3 inflammasomes.