Objective To explore the changes of plasma Clara cell secretory protein (CC16) and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease (COPD).
Methods The clinical data of 94 COPD patients and 43 healthy people admitted to the Renhe Hospital of Baoshan District in Shanghai from March 2019 to June 2020 were retrospectively analyzed. Study subjects were divided into stable COPD group (n=49), acute exacerbation COPD group (n=45), and healthy group (n=43). The levels of plasma CC16 and arterial blood gas related parameters (arterial oxygen pH, arterial partial pressure of oxygenPaO2, arterial partial pressure of carbon dioxidePaCO2, arterial oxygen saturationSaO2) were compared among the three groups. Pearson correlation analysis was used to explore the correlation between the changes of plasma CC16 levels and arterial blood gas related parameters in COPD patients.
Results The levels of plasma CC16, pH, PaO2 and SaO2 in the healthy group were higher than those in the stable COPD group, and which in the stable COPD group were higher than those in the acute exacerbation COPD group, with statistically significant differences (P < 0.05). The PaCO2 in the stable COPD group and the acute exacerbation COPD group were higher than that in the healthy group, and which in the acute exacerbation COPD group was higher than that in the stable COPD group (P < 0.05). The levels of plasma CC16 were positively correlated with pH, PaO2, and SaO2 in the stable COPD group (r=0.752, 0.824, 0.874), the acute exacerbation COPD group (r=0.768, 0.856, 0.917), and COPD patients (r=0.759, 0.839, 0.887), whereas negatively correlated with PaCO2 (r=-0.819, -0.835, -0.820), all P < 0.05.
Conclusions There are correlations between plasma CC16 levels and arterial blood gas parameters in stable and acute exacerbation COPD patients, and the changes in acute exacerbation COPD patients are significantly greater than those in stable COPD patients.
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