Objective To explore the correlation between NT-proBNP level and coronary artery occlusion in patients with the non-ST-elevation acute coronary syndrome (NSTE-ACS) and its evaluation value.
Methods 223 patients with NSTE-ACS admitted to Tai'an Central Hospital from December 2017 to December 2019 were selected. According to the results of coronary angiography, the patients were divided into non occlusive disease group(n=156) and occlusive disease group(n=67). The NT-proBNP level of the two groups was measured and compared. The risk factors of coronary occlusion were analyzed by logistic regression, and the diagnostic value of NT-proBNP for NSTE-ACS occlusive lesions was evaluated by ROC curve.
Results Compared with the non-coronary occlusion group, the level of NT-proBNP in the coronary occlusion group was significantly higher (P < 0.001); multivariate logistic regression analysis showed that high level of NT-proBNP was an independent risk factor for the presence of coronary occlusion in NSTE-ACS (OR=1.011, 95% CI 1.001-1.012, P=0.002). The area under ROC curve of NT-proBNP was 0.724 (95% CI 0.638-0.810), and the best cut-off point was 149.50 ng/L, sensitivity 80.6%, specificity 61.5%.
Conclusions In NSTE-ACS patients with coronary occlusion, the level of NT-proBNP is increased. It is of certain value to the diagnosis of NSTE ACS occlusion.
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