Effect of menopausal status on long-term outcome of women undergoing drug-eluting stent implantation

Objective To explore the relationship between menopausal status and long-term outcome of patients with coronary heart disease (CHD) after drug-eluting stent implantation.

Methods The data of 143 patients with CHD who were less than 55 years old and implanted with drug-eluting stents in Zhongshan Hospital, Fudan University from January 2008 to December 2014 were retrospectively analyzed. According to the status of menopause, patients were divided into premenopausal women group (n=50) and postmenopausal women group (n=93).

Results Compared with the postmenopausal women, the premenopausal women were younger, and had a higher rate of positive family history of CHD. The median follow-up time was 823 days. The incidence of major cardiac adverse events (MACEs) was not significantly different between the two groups. The event-free survival rate was not significantly different between the two groups. Cox regression analysis showed that the independent predictors of MACEs included the multi-vessel disease and lower estimated GFR other than menopausal status.

Conclusions In women with CHD, the premenopausal status might not be a influence factor for MACEs.