Research progress of the relationship between arginine methyltransferase and tumor

Protein arginine methyltransferases (PRMTs) mediate the methylation of a series of arginine residue protein substrates, and play a key role in the occurrence, development, and invasion of cancer. In this paper, the association between 9 types of PRMT family members and cancer was reviewed. Currently, there are more studies on the relationship between PRMT1, PRMT5 and different types of tumors, while the mechanism of other types (such as PRMT2, PRMT3, PRMT4, and PRMT7) in tumor is still unclear. Some PRMTs have become potential targets for cancer treatment. Currently, several studies have been conducted to develop PRMT inhibitors for treating malignant tumors. Future studies should further focus on the effects of PRMT inhibitors on cancer cells, immune cells, and inflammatory factors, and explore therapeutic targets, so as to provide precise treatment for PRMTs-related tumors.