The effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients

Objective To observe the effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients.

Methods The data of 12 patients with liver cancer who received PD-1 inhibitor before liver transplantation between January 1 and December 31, 2019 in Zhongshan Hospital, Fudan University were analyzed. The concentration of tacrolimus in the early postoperative period were detected and the occurrence of rejection after transplantation were observed.

Results The tacroliums concentration at 1week or 2 week after liver transplantation were (5.14±2.68) ng/mL and (8.41±5.73) ng/mL. The incidence of rejection after liver transplantation was only 16.7%(2/12).

Conclusion The incidence of rejection after liver transplantation is not significantly increased in patients with liver cancer who use PD-1 inhibitors before liver transplantation.