Citation: | Working Group of Novel Coronavirus Pneumonia. Guideline for the diagnosis and clinical management of suspected novel coronavirus pneumonia in Zhongshan Hospital, Fudan University (2020 v.1)[J]. Chin J Clin Med, 2020, 27(1): 13-15. DOI: 10.12025/j.issn.1008-6358.2020.20200263 |
The key of novel coronavirus pneumonia (NCP) management is early detection, early diagnosis, early isolation, early treatment based on 'the diagnosis and treatment of new coronavirus pneumonia' (v5) according of National Health Commission of the People's Republic of China. The management of NCP suspected cases is to avoid missed diagnosis, improve treatment rate, avoid delay in diagnosis and prevent infection. However, observation, isolation conditions, admission criteria, discharge criteria remain unclear. Learning from practice, the clinical symptom and the ground glass changes on chest CT scan appeared earlier than the positive for RT-PCR test in some cases. Repeat testing is recommended in clinical suspected cases with an initially negative result of nasopharyngeal swab samples. And the sensitivity and specificity of RT-PCR testing need to be verified. The clinical NCP suspected cases should be admitted in hospital with isolation and management. During the stay in the hospital, we suggest to repeat testing the samples of nasopharyngeal swab, sputum, feces, blood, lower respiratory secretions and alveolar lavage fluids, if allowed. The discharge criteria of these patients are similar to the NCP confirmed cases. To ensure that discharged patients do not carry the virus, to achieve the dual safety of patients and the community.
[1] |
ZHU N, ZHANG D Y, WANG W L, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, [Online ahead of print].
|
[2] |
LI Q, GUAN X H, WU P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus infected pneumonia[J]. N Engl J Med, 2020, [Online ahead of print].
|
[3] |
陈大明, 赵晓勤, 缪有刚, 等.全球冠状病毒研究态势分析及其启示[J].中国临床医学, 2020, 27(1):1-12. http://www.c-jcm.com/zglcyx/ch/reader/view_abstract.aspx?file_no=20200101&flag=1
|
[4] |
国家卫生健康委办公厅和国家中医药管理局办公室. 《新型冠状病毒感染的肺炎诊疗方案》(试行第五版).http://www.nhc.gov.cn/(20202.12).
|
[5] |
SHE J, JIANG J J, YE L et al. 2019 novel coronavirus of pneumonia in WuHan, China: emerging attack and management strategies[J]. Clin Transl Med, 2020, [Accept].
|
[6] |
MEMISH Z A, AL-TAWFIQ J A, MAKHDOOM H Q, et al. Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome[J]. J Infect Dis, 2014, 210(10):1590-1594. DOI: 10.1093/infdis/jiu292
|
[7] |
HUNG I F, CHENG V C, WU A K, et al. Viral loads in clinical specimens and SARS manifestations[J]. Emerg Infect Dis, 2004, 10(9):1550-1557. DOI: 10.3201/eid1009.040058
|
[8] |
CHAN JASPER F W, YUAN S F, KOK K H, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster[J]. Lancet, 2020, [Online ahead of print].
|
[9] |
HOLSHUE M L, DEBOLT C, LINDQUIS S, et al. First case of 2019 novel coronavirus in the United States[J]. N Engl J Med, 2020, [Online ahead of print].
|
[10] |
CHEN N S, ZHOU M, DONG X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J]. Lancet, 2020, [Online ahead of print].
|
[11] |
WANG D W, HU B, HU C et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China[J]. JAMA, 2020, [Online ahead of print].
|
[12] |
HUANG C L, WANG Y M, LI X W, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, [Online ahead of print].
|