Correlation between serum phosphorus and vibration perception threshold in patients with type 2 diabetes mellitus

Objective：To explore the correlation between serum phosphorus (P) and vibration perception threshold (VPT) in patients with type 2 diabetes mellitus (T2DM). Methods：A total of 1 027 patients with T2DM were enrolled in this study. They were stratified according to VPT: vibration sensation normal group (n=535), vibrational hypoesthesia group (n=294), and vibration sensation deficiency group (n=198). The correlation between serum P and VPT was evaluated by Spearman correlation analysis and Stepwise multiple stepwise regression analysis. Results：Compared with the vibration sensation normal group, the age and duration of the vibrational hypoesthesia group and vibration sensation deficiency group were older and longer （P＜0.05）. Compared with the normal group, eGFR and P of the vibrational hypoesthesia group and vibration sensation deficiency group decreased significantly （P＜0.05）. Compared with the vibrational hypoesthesia group, eGFR and P of vibration sensation deficiency group decreased significantly （P＜0.05）. Spearman correlation analysis showed that age （r=0.454, P＜0.001） and duration （r=0.289, P＜0.001） were positively correlated with VPT, while eGFR （r=-0.251, P＜0.001） and P （r=-0.145, P＜0.001） were negatively correlated with VPT. Multiple stepwise regression analysis showed that age, duration, HBA1c, eGFR, and P were independent risk factors for VPT. Conclusions：Serum P is positively correlated with VPT and is an independent risk factor for VPT in patients with type 2 diabetes mellitus.