Clinical strategy for treatment of patients with recurrent or metastatic solitary fibrous tumor

Objective：To explore the clinical strategy for treatment for patients with recurrent or metastatic solitary fibrous tumor. Methods：The clinical data and follow-up data of 19 patients with recurrent or metastatic solitary fibrous tumor admitted to Zhongshan Hospital, Fudan University from January 2012 to October 2018 were collected, and the curative effects of local treatment and drug therapy were analyzed. Results：Ten patients underwent operation after recurrence or metastasis. Among the patients without operation, 4 patients were treated with radiotherapy, 2 patients were treated with interventional therapy, and 3 patients with extensive metastasis were treated with drug therapy (1 combined with interventional therapy). Nineteen patients were followed up for 7-79 months, with a median follow-up of 43 months. The 1-year overall survival rate was 94.7% (18/19) and the 2-year overall survival rate was 73.7% (14/19). Conclusions：The progress of recurrent or metastatic solitary fibrous tumor is slow. Local recurrence is common and distant metastasis can also occur. Re-operation has reliable curative effect. Non-resectable patients can be treated with local therapy (interventional or radiotherapy) combined with drug therapy.