Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma

Objective：To investigate the expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma (ICC). Methods：The expression of TRIM44 and MMP9 in 87 ICC patients were analyzed by immunohistochemistry. And the clinical significance of TRIM44 and MMP9 were investigated by Kaplan-Meier and Cox regression models. Results：The expressions of TRIM44 and MMP9 were upregulated in tumor tissues of ICC. TRIM44 was positively associated with MMP9 expression in ICC (P<0.001). TRIM44 expression was significantly correlated with the lymph node metastasis (P=0.014), and MMP9 was significantly correlated with the tumor size, AFP concentration, and lymph node metastasis (P<0.05). Simultaneous overexpression of TRIM44 and MMP9 suggested poor prognosis of ICC patients. Conclusions：TRIM44 and MMP9 are overexpressed in ICC and are closely related to each other. The high expressiones of both suggest poor prognosis of ICC patients.