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ZHANG Rui-qing, XU Xian-ming, ZHANG Jia-rong. Relationship between free fatty acids and preeclampsia and gestational diabetes mellitus[J]. Chin J Clin Med, 2018, 25(5): 720-723. DOI: 10.12025/j.issn.1008-6358.2018.20180161
Citation: ZHANG Rui-qing, XU Xian-ming, ZHANG Jia-rong. Relationship between free fatty acids and preeclampsia and gestational diabetes mellitus[J]. Chin J Clin Med, 2018, 25(5): 720-723. DOI: 10.12025/j.issn.1008-6358.2018.20180161

Relationship between free fatty acids and preeclampsia and gestational diabetes mellitus

Funds: Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Open Project(14DZ2271700)and “Research Physician” and “Clinical Full-time Research Team” Project(20172020).
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  • Objective:To investigate the effect of free fatty acid (FFA) on the incidence of preeclampsia and/or gestational diabetes mellitus (GDM) during late pregnancy. Methods:A total of 417 pregnant women with preeclampsia and/or GDM were selected as the observation group, and another 2 018 normal pregnant women as the control group. The levels of serum lipids including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and free fatty acid (FFA) were measured and compared between the two groups. The association between lipid metabolism and pregnancy complications were analyzed by logistic regression models. Results:After adjusting for confounding factors, including pre-pregnancy body mass index (BMI), maternal age and gestational age at blood sampling, FFA concentrations measured during late pregnancy were associated with a significantly increased risk of preeclampsia, GDM and composite of preeclampsia and GDM(P<0.01). Furthermore, elevated maternal TG levels increased the risk of preeclampsia (P<0.001). Conclusions:FFA levels during late pregnancy show strong relationships with the incidence of preeclampsia or GDM.

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