Progress of the interferon regulatory factors in the development of tumor

Interferon regulatory factors (IRFs), which have 10 members, belong to the transcription factor family, and are named because of the regulation of interferon expression. They play important roles in the immune regulation, cell differentiation, cell apoptosis, and cell cycle regulation. This article will review the functional characteristics and immune activity of the family members, especially in the role of cell differentiation and tumor development.