Clinical-pathological characteristics and treatment of ovarian immature teratoma

Objective：To investigate the clinicalpathological characteristics of ovarian immature teratoma and the effects of different surgery methods (cystectomy, salpingooophorectomy and hysterectomy+ bilateral salpingooophorectomy) on the prognosis of the patients and to analyze the role of cystectomy for apparent earlystage ovarian immature teratoma. Methods：Clinical data of 50 patients who were pathologically diagnosed with immature teratoma between Jul. 1997 and Aug. 2015 at the Obstetrics and Gynecology Hospital of Fudan University were analyzed retrospectively. According to the surgery methods, these patients were divided into three groups. The clinicalpathological characteristics and the prognosis of disease were compared. Results：All 50 cases were participated in the study. The followup time was 3207 months. FIGO stage as follows：ⅠA (34 patients), ⅠC1(10 patients), ⅠC2 (3 patients) and ⅡB, ⅢB and ⅢC (1 patient). Patients were divided into cystectomy group, salpingooophorectomy group and hysterectomy and bilateral salpingooophorectomy group. The five year diseasefree survival (DFS) was 100%,86.8%,100%, respectively. There were 45 patients underwent fertilitysparing surgery, 42 patients were the apparently early stage. No patient died among 50 cases, the total five year DFS rate was 91.0%.Among 50 cases, 4 cases were relapsed, and 3 cases had supplement surgery, 1 case was received assisted treatment, the postoperative pathology indicated that the recurrence was mature teratoma. Among 45 cases, 44 cases had normal period, only 1 case has shorten the period time. There were 13 patients with fertility requirements after surgery, including 11 cases of successful pregnant,and delivered 11 healthy infants, 2 cases were infertility (1 case due to tubal factor, 1 case of unexplained). Conclusions：Majority of patients are diagnosed with ovarian immature teratoma at an early stage. The data suggested that cystectomy could be considered for apparent earlystage patients affected by pure immature teratoma without adverse impact upon survival. Chemotherapy regimen is determined by pathological grade.