| Expression of m6A methyltransferase like 3 in pan-tumor and its effect on tumor microenvironment |
| Received:October 08, 2023 Revised:November 27, 2023 Click here to download the full text |
| Citation of this paper:FEI Xia-wei,ZHANG Ju-gen,DAI Li-yang,WU Zhen-qi,SHEN Yan-ting,LI Hui-feng.Expression of m6A methyltransferase like 3 in pan-tumor and its effect on tumor microenvironment[J].Chinese Journal of Clinical Medicine,2023,30(6):1027-1032 |
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| Author Name | Affiliation | E-mail | | FEI Xia-wei | Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China | | | ZHANG Ju-gen | Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China | | | DAI Li-yang | Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China | | | WU Zhen-qi | Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China | | | SHEN Yan-ting | Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
Department of Urology and Andrology, Gongli Hospital, Navy Medical University, Shanghai 200135, China | shenyanting798@126.com | | LI Hui-feng | Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China | urologylihf1301@sina.com |
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| Abstract:Objective To analyze the expression of m6A methyltransferase like 3 (METTL3) gene in pan-tumor and its effect on tumor microenvironment. Methods The Cancer Genome Atlas (TCGA) database was used to analyze the gene sequencing and clinical data of patients with various tumors. The expressions of METTL3 gene in various tumors and its correlations with prognosis and tumor microenvironment were analyzed. Results METTL3 gene expression was upregulated in most malignancies, but only was associated with poor PFS of patients with hepatocellular carcinoma and prostate cancer (P<0.05). The expression of METTL3 gene was associated with the infiltration levels of many inmmunet cells in hepatocellular carcinoma and prostate cancer, as well as the expression levels of inhibitory immune checkpoint genes (P<0.05). Conclusions METTL3 gene overexpression could affect the prognosis of hepatocellular carcinoma and prostate cancer, which maybe associated with immune invasion and inhibitory immune checkpoints increased. |
| keywords:m6A methyltransferase like 3 bioinformatics pan-tumor tumor microenvironment immune infiltration |
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