| Research progress on trained immunity in tumor multimodality therapy |
| Received:August 25, 2023 Revised:September 14, 2023 Click here to download the full text |
| Citation of this paper:BU Yi-chao,FU Xiu-tao,DING Zhen-bin,LIU Wei-ren,SHI Ying-hong,FAN Jia,TANG Zheng.Research progress on trained immunity in tumor multimodality therapy[J].Chinese Journal of Clinical Medicine,2023,30(5):861-869 |
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| Author Name | Affiliation | E-mail | | BU Yi-chao | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | FU Xiu-tao | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | DING Zhen-bin | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | LIU Wei-ren | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | SHI Ying-hong | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | FAN Jia | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | | | TANG Zheng | Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai 200032, China | tang.zheng@zs-hospital.sh.cn |
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| Abstract:The classical immune system is divided into innate immunity and acquired immunity. The general view is that immune memory exists only in acquired immunity. However, in organisms lacking adaptive immunity, cells of the innate immune system are able to acquire memory signatures after a brief stimulus, thereby enhancing the response upon a secondary stimulus, a phenomenon known as training immunity. Trained immunity can play a unique anti-tumor role in tumors. In bladder cancer, training immunity induced by BCG vaccine has become the standard treatment for bladder cancer. The efficacy of BCG in the treatment of melanoma has also been recognized in recent years. Improving immune training during therapy through irreversible electroporation (IRE) can prolong survival in patients with pancreatic cancer. Whole β-glucan particle (WGP) can inhibit tumor lung metastasis. In breast cancer, the introduction of drugs through nanoparticles (NPs) can improve the training immune effect of targeted sites. This paper reviews the concepts, mechanisms, and current status of training immunity in the field of oncology therapy. |
| keywords:trained immunity innate immune memory immune microenvironment tumor therapy |
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