| The expression and prognostic value of IL-34 in lung adenocarcinoma with epidermal growth factor receptor mutation |
| Received:April 09, 2023 Revised:May 31, 2023 Click here to download the full text |
| Citation of this paper:JI Shi-meng,JIANG Jia-hao,HU Jie,SONG Yuan-lin.The expression and prognostic value of IL-34 in lung adenocarcinoma with epidermal growth factor receptor mutation[J].Chinese Journal of Clinical Medicine,2023,30(3):421-425 |
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| Author Name | Affiliation | E-mail | | JI Shi-meng | Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Pulmonary Medicine, Shanghai Geriatric Medical Center, Shanghai 201104, China
Shanghai Respiratory Research Institute, Shanghai 200032, China | | | JIANG Jia-hao | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HU Jie | Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Pulmonary Medicine, Shanghai Geriatric Medical Center, Shanghai 201104, China
Shanghai Respiratory Research Institute, Shanghai 200032, China | | | SONG Yuan-lin | Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Pulmonary Medicine, Shanghai Geriatric Medical Center, Shanghai 201104, China
Shanghai Respiratory Research Institute, Shanghai 200032, China | ylsong70@163.com |
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Abstract:Objective To detect the expression level of interleukin-34 (IL-34) in lung adenocarcinoma (LUAD) with epidermal growth factor receptor (EGFR) mutant and to investigate the relationship between IL-34 and prognosis in these patients. Methods A total of 144 LUAD patients with EGFR mutant were enrolled, who had not received any chemotherapy, immunotherapy or radiotherapy before surgery and underwent resection from July 2015 to December 2017 in Zhongshan Hospital, Fudan University. The immunohistochemistry (IHC) was uesd to detect the expression of IL-34 in tumor and paired normal lung tissues. Kaplan-Meier curve and Cox model were used to analyze the association of IL-34 with the prognosis of patients. Results Compared with paired normal tissues, IL-34 was overexpressed in tumor tissues in LUAD patients. The follow-up time was 64(42, 73) months. Kaplan-Meier curve showed that the patients in high IL-34 group (n=93) had lower overall survival rate (P=0.006) and higher accumulation recurrence rate (P=0.011) than the patients in the low IL-34 group (n=51). Cox model analysis showed that
IL-34 expression was an independent predictor of overall survival (HR=2.218, P=0.015) and recurrence (HR=2.486, P=0.018) of patients. Conclusion IL-34 could be used to predict prognosis of LUAD patients with EGFR mutation. |
| keywords:interleukin-34 lung adenocarcinoma epidermal growth factor receptor prognosis |
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