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Research progress on the mechanism of itch sensitization in atopic dermatitis
Received:April 08, 2023  Revised:August 11, 2023  Click here to download the full text
Citation of this paper:QIAN Wei-lu,CAI Tao.Research progress on the mechanism of itch sensitization in atopic dermatitis[J].Chinese Journal of Clinical Medicine,2023,30(5):908-913
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Author NameAffiliationE-mail
QIAN Wei-lu Department of Dermatology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China  
CAI Tao Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China caidaodao@hotmail.com 
Abstract:Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritus. Small stimulation can induce patient’s hyperactive desire to scratch, which is manifested as itch sensitization. Itch sensitization includes hyperknesis and alloknesis. The joint action of nerve, immunity and skin barrier leads to the occurrence of itch sensitization. This article reviews the research progress in the sensitization mechanism of atopic skin itching in recent years.
keywords:atopic dermatitis  hyperknesis  alloknesis  chronic pruritus
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