| Analysis of the whole blood thiamine level and its contributing factors among elderly people in a Shanghai community |
| Received:April 06, 2023 Revised:April 23, 2023 Click here to download the full text |
| Citation of this paper:PAN Xiao-li,CHENG Xiao-qin,SANG Shao-ming,CAI Wen-wen,HUANG Qiang,FEI Guo-qiang.Analysis of the whole blood thiamine level and its contributing factors among elderly people in a Shanghai community[J].Chinese Journal of Clinical Medicine,2023,30(2):215-220 |
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| Author Name | Affiliation | E-mail | | PAN Xiao-li | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHENG Xiao-qin | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SANG Shao-ming | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CAI Wen-wen | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | HUANG Qiang | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | FEI Guo-qiang | Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Neurology, Zhongshan Hospital, Fudan University(Xiamen Branch), Xiamen 361015, Fujian, China | fl0817@126.com |
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| Abstract:Objective To analyze the level of thiamine and its main phosphate derivatives in whole blood among the elderly population in a Shanghai community, and explore its contributing factors. Methods A total of 2 330 elderly people were recruited from a community in Xuhui District, Shanghai from April 2012 to December 2014. The information of age, education, height, weight, body mass index (BMI) and medical history was collected through questionnaires. The cognitive function was evaluated by Mini-Mental Status Examination (MMSE), and the blood routine, liver and kidney function, fasting blood glucose, triglyceride levels were measured. The whole blood thiamine diphosphate (TDP), thiamine monophosphate (TMP), and free thiamine levels were detected by high performance liquid chromatography (HPLC). A multivariate linear regression model was used to analyze the contributing factors of whole blood TDP, TMP and free thiamine levels. Results A total of 1 685 elderly people were included, with an average age of (72.78±5.94) years. There were 747 male and 938 female. The levels of TDP, TMP and free thiamine were (115.22±25.30) nmol/L, (7.93±5.80) nmol/L and (3.53±3.31) nmol/L, respectively. Multivariate linear regression model showed a significant correlation between TDP level and male (β＝3.304, 95%CI 0.099-6.509, P＝0.043), years of education (β＝0.367, 95%CI 0.079-0.665, P＝0.013), BMI (β＝0.520, 95%CI 0.123-0.916, P＝0.010), hemoglobin (β＝0.435, 95%CI 0.330-0.540, P＜0.001), creatinine (β＝-0.093, 95%CI-0.176--0.010, P＝0.028). There was a significant correlation between TMP level and male (β＝1.818, 95%CI 1.067-2.569, P＜0.00), years of education (β＝0.137, 95%CI 0.069-0.204, P＜0.001), hemoglobin (β＝0.082, 95%CI 0.058-0.107, P＜0.001), fasting plasma glucose (β＝-0.416, 95%CI-0.624--0.208, P＜0.001), triglyceride (β＝-0.417, 95%CI-0.743--0.092, P＝0.012). There was a significant correlation between free thiamine level and male (β＝0.944, 95%CI 0.513-1.375, P＜0.001), hemoglobin (β＝-0.018, 95%CI-0.032--0.004, P＝0.014), triglyceride (β＝-0.228, 95%CI-0.414--0.042, P＝0.016), alanine aminotransferase (β＝0.019, 95%CI 0.003-0.035, P＝0.018). Conclusions Multiple factors may affect thiamine and its main phosphate derivatives in whole blood, among which male, advanced education, hemoglobin level and BMI are positively correlated with TDP. It is suggested that women, elderly people with low level of hemoglobin and abnormal BMI in the community should prevent the risk of thiamine deficiency and related diseases. |
| keywords:thiamine thiamine diphosphate thiamine monophosphate elderly people in community contributing factors |
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