| Application progress of non-traditional diuretics in patients with exacerbation of chronic heart failure |
| Received:February 21, 2023 Revised:March 21, 2023 Click here to download the full text |
| Citation of this paper:CHEN Shao-ping.Application progress of non-traditional diuretics in patients with exacerbation of chronic heart failure[J].Chinese Journal of Clinical Medicine,2023,30(6):1051-1055 |
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| Abstract:Loop diuretics are the cornerstone of worsening heart failure (HF) therapy. However, an important challenge faced by HF patients is that despite taking a large amount of loop diuretics, they still exhibit fluid overload. There is no enough evidence of diuretics reducing the mortality of HF patients. Brain natriuretic peptides enhancer and sodium-glucose transporter 2 inhibitors with unique natriuretic effect, can improve neurohormonal activation without increasing renal injury and electrolyte disturbance. Combined with loop diuretics, they can increase urine volume in the short term and improve the prognosis in the long term, providing a new paradigm for the management of worsening HF. |
| keywords:worsening heart failure loop diuretics brain natriuretic peptide sodium-glucose transporter 2 inhibitor |
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