| Predictive value of NLR and MPV for short-term and long-term adverse events after PCI in patients with acute coronary syndrome |
| Received:January 27, 2023 Revised:February 16, 2023 Click here to download the full text |
| Citation of this paper:HUANG Kai-jian,LI Jian-xuan,CHANG Shu-fu,LI Chen-guang,LU Hao,HUANG Jia,ZHU Li,DAI Yu-xiang,YAN Chun-xi,QIAN Ju-ying,GE Jun-bo.Predictive value of NLR and MPV for short-term and long-term adverse events after PCI in patients with acute coronary syndrome[J].Chinese Journal of Clinical Medicine,2023,30(1):56-63 |
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| Author Name | Affiliation | E-mail | | HUANG Kai-jian | Department of Cardiology, Qidong People's Hospital, Nantong University Affiliated Qidong Hospital, Qidong 226200, Jiangsu, China
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | LI Jian-xuan | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | CHANG Shu-fu | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | LI Chen-guang | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | LU Hao | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | HUANG Jia | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | ZHU Li | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | zhu.li@zs-hospital.sh.cn | | DAI Yu-xiang | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | dai.yuxiang@zs-hospital.sh.cn | | YAN Chun-xi | Department of Cardiology, Qidong People's Hospital, Nantong University Affiliated Qidong Hospital, Qidong 226200, Jiangsu, China | | | QIAN Ju-ying | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | | | GE Jun-bo | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China | |
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| Abstract:Objective To explore the predictive value of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) for short-and long-term adverse events in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods A total of 2225 ACS patients treated with PCI from GRAND and GRAND-EXTENDED studies were included. The patients were grouped into high-NLR (n=557), low-NLR (n=1 668), groups and high-MPV (n=577), low-MPV (n=1 635), groups according to the 75th percentile of NLR or MPV. The incidences of intraoperative no-reflow/slow-flow, in-hospital major adverse cardiac events (MACE) and 1-year MACE after surgery were analyzed in the different NLR or MPV groups. Multiple logisti regression was used to analyze the independent influencing factors of adverse events. ROC was used to analyze predict values of NLR and/or MPV for adverse events. Results Compared with low-NLR group the incidences of intraoperative no-reflow/slo-flow, in-hospital MACE and 1-year MACE after surgery were significantly higher than those in high-NLR group (11.7% vs 5.1%, 13.5% vs 8.5% and 35.0% vs 10.8%, respectively; P＜0.05). The incidences of intraoperative no-reflow/slow-flow, in-hospital MACE, and 1-year MACE after surgery in high-MPV group were also significantly higher than those in low-MPV group (12.1% vs 4.8%, 17.3% vs 7.0%, and 29.6% vs 12.2%, respectively; P＜0.05). After adjustment for confounding factors, NLR still was the an independent influence for no reflow/slow-flow (OR＝1.04, 95%CI 1.01-1.06) and 1-year MACE after surgery (OR=1.01, 95%CI 1.00-1.07, P＜0.05). MPV was an independent influence for 1-year MACE after surgery (OR＝1.02, 95%CI 1.00-1.05, P＜0.05). The AUC of combination of NLR and MPV in predicting short-term and long-term adverse events was 0.701, 0.698 and 0.766, respectively, which were higher than the single index (P＜0.05). Conclusions ACS patients with high NLR or MPV may have higher rates of short-term and long-term adverse events, and combination of NLR and MPV has higher predictive value. |
| keywords:neutrophil to lymphocyte ratio mean platelet volume acute coronary syndrome percutaneous coronary intervention therapy adverse events predictive value |
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