| Research progress in the therapeutic effect and biological mechanisms of tibial transverse transport for diabetic foot |
| Received:January 19, 2023 Revised:February 15, 2023 Click here to download the full text |
| Citation of this paper:LIN Shi-hong,YANG Xiong-gang,GENG Xiang,WANG Xu,MA Xin.Research progress in the therapeutic effect and biological mechanisms of tibial transverse transport for diabetic foot[J].Chinese Journal of Clinical Medicine,2023,30(1):12-17 |
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| Author Name | Affiliation | E-mail | | LIN Shi-hong | Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China | | | YANG Xiong-gang | Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China | | | GENG Xiang | Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China | | | WANG Xu | Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China | wangxuanklehuashan@163.com | | MA Xin | Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China | |
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| Abstract:In recent years, the aging population structure has led to an increase in the number of diabetic patients, and more and more scholars are using the tibial transverse transport technique as an option to treat diabetic foot. The TTT technique is a surgical technique based on the principle of “tension-stress” effect, which transforms mechanical stimuli into biological signals to promote wound healing in diabetic foot ulcers by improving microcirculation. The technique improves the microcirculation through a number of biological mechanisms, such as skylight opening effect; promoting the secretion of cytokines; macrophage polarization balance reconstruction; and stem cell mobilization. Therefore, this paper will briefly review the principle and steps of the TTT technique, and its biological mechanism of improving foot microcirculation in diabetes. |
| keywords:tibial transverse transport diabetic foot ulcer microcirculation |
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