| The regulation effect of NaV1.8 channels on atrial fibrillation inducibility after acute myocardial infarction |
| Received:October 27, 2022 Revised:February 18, 2023 Click here to download the full text |
| Citation of this paper:QI Bao-zhen,XIE Zhong-lei,SHEN Dong-li,DAI Shi-mo,ZHANG Chun-yu,LIN Jia-xiong,LIU Shao-wen,NIE Zhenning,ZHOU Jing-min,QIAN Ju-ying,GE Jun-bo.The regulation effect of NaV1.8 channels on atrial fibrillation inducibility after acute myocardial infarction[J].Chinese Journal of Clinical Medicine,2023,30(2):301-305 |
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| Author Name | Affiliation | E-mail | | QI Bao-zhen | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | XIE Zhong-lei | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | SHEN Dong-li | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | DAI Shi-mo | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | ZHANG Chun-yu | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | LIN Jia-xiong | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | LIU Shao-wen | Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China | | | NIE Zhenning | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | nie.zhenning@zs-hospital.sh.cn | | ZHOU Jing-min | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | zhou.jingmin@zs-hopital.sh.cn | | QIAN Ju-ying | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | | | GE Jun-bo | Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai 200032, China | |
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| Abstract:Objective To explore the effects of blocking NaV1.8 channels in cardiac ganglionated plexi (GP) on atrial fibrillation after acute myocardial infarction. Methods A total of 12 male beagles were randomly enrolled. NaV1.8 channels blocker A-803467 (n＝6) or DMSO (n＝6, control) was injected. Sinus rate (SR), atrial effective refractory period (AERP), the atrial cumulative window of vulnerability and duration of atrial fibrillation were measured before and 30 min, 60 min, 90 min after A-803467 or DMSO injection. The SR changes induced by high-frequency electrical stimulation (20 Hz, 0.1 ms, square wave) in the right anterior GP were recorded 10 min after injection. Results Compared with the control group, A-803467 significantly increased SR, shortened the AERP, widened the atrial cumulative window of vulnerability and prolonged the duration of atrial fibrillation. In addition, A-803467 suppressed the SR slowness induced by high-frequency electrical stimulation of the right anterior GP. Conclusions Blocking NaV1.8 increases the atrial fibrillation inducibility after acute myocardial infarction, and the underlying mechanism may be related to the regulation of the neural activity of the cardiac GP. |
| keywords:atrial fibrillation acute myocardial infarction sodium channel cardiac ganglionated plexi electrophysiology |
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