| Effect of neutrophil extracellular traps and multidrug resistant bacteria infection on prognosis of patients with severe pneumonia |
| Received:September 04, 2022 Revised:November 20, 2022 Click here to download the full text |
| Citation of this paper:DING Hai-ling,WANG Jian-li,XU Fei-xiang.Effect of neutrophil extracellular traps and multidrug resistant bacteria infection on prognosis of patients with severe pneumonia[J].Chinese Journal of Clinical Medicine,2022,29(6):921-925 |
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| Author Name | Affiliation | E-mail | | DING Hai-ling | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Jian-li | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | XU Fei-xiang | Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai 200032, China | xu.feixiang@zs-hospitlal.sh.cn |
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| Abstract:Objective To explore the effect of neutrophil extracellular traps (NETs) on the multidrug resistance (MDR) bacteria-induced severe pneumonia. Methods A total of 171 severe pneumonia patients were enrolled and divided into MDR group (n＝86) and non-MDR group (n＝85). Clinical data and biochemical indices were compared between the two groups. Kaplan-Meier method and Cox proportional hazard model were used to analyze survival rate of patients and predictors. Results Compared with non-MDR group, the NETs level, SOFA score and APACHE Ⅱ score increased in the MDR group (P＜0.01). NETs level was positively correlated with the SOFA score (r＝0.202, P＝0.008) and APACHE Ⅱ score (r＝0.408, P＝0.001). There was significant difference in survival rate between MDR and non-MDR groups (58.48% vs 84.70%, P＝0.000 3). Univariate Cox regression analysis showed that NETs affected prognosis of patients with severe pneumonia (HR＝1.000 2，95%CI 1.000 1-1.000 2, P=0.002). Multivariate Cox regression analysis showed that grouping was the independent prognostic factor for survival of patients (HR=0.288，95%CI 0.151-0.548, P＝0.000 1). Conclusion NETs increase in patients with severe pneumonia induced by MDR bacteria, which may be a factor influencing the prognosis of these patients, and patients with MDR bacteria infection had worse prognosis. |
| keywords:neutrophil extracellular traps multidrug-resistant bacteria severe pneumonia prognosis |
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