| Sedative and analgesic effects of fentanyl combined with midazolam in mechanical ventilation of premature infants |
| Received:July 30, 2022 Revised:October 13, 2022 Click here to download the full text |
| Citation of this paper:YANG Jing-yue,XU Mei-yu,WU You-jia,SHEN Fei-fei,SUO Gui-hai,LI Hai-ying.Sedative and analgesic effects of fentanyl combined with midazolam in mechanical ventilation of premature infants[J].Chinese Journal of Clinical Medicine,2022,29(6):939-944 |
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| Author Name | Affiliation | E-mail | | YANG Jing-yue | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | | | XU Mei-yu | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | | | WU You-jia | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | | | SHEN Fei-fei | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | | | SUO Gui-hai | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | | | LI Hai-ying | Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China | zl070619@126.com |
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| Abstract:Objective To explore the sedative and analgesic effects of fentanyl and midazolam in mechanical ventilation of premature infants. Methods 90 premature infants with respiratory distress syndrome who received mechanical ventilation in neonatal ward of the Affiliated Hospital of Nantong University from June 2017 to April 2021 were selected and randomly divided into four groups. After intubation, infants in group F (n＝23) received intravenous infusion of fentanyl 2 μg·kg-1·h-1; those in group M (n＝23) received intravenous infusion of midazolam 0.1 mg·kg-1·h-1; those in group FM (n＝22) received fentanyl 2 μg·kg-1·h-1 combined with midazolam 0.1 mg·kg-1·h-1; those in group FMH (n＝22) received fentanyl 1 μg·kg-1·h-1 combined with midazolam 0.05 mg·kg-1·h-1. The neonatal pain, agitation and sedation scale (N-PASS) score, peak inspiratory pressure (PIP), inhaled oxygen concentration (FiO2), respiratory rate (RR), heart rate (HR), mean blood pressure (MBP), and blood glucose (Glu) were compared before and at 4, 8, 12 and 24h after treatment. The duration of mechanical ventilation, oxygen therapy time, adequate enteral feeding time, length of hospital stay, and short-term side effects were compared among the four groups. Results There were significant differences in N-PASS score, PIP and RR among 90 infants at different time points and in different groups (P＜0.05). There were significant differences in FiO2, HR, MBP, and Glu at different time points (P＜0.05). After treatment, N-PASS score at 4, 8, 12 and 24h in group FM and FMH were significantly lower than those in group F and M (P＜0.05); PIP and RR at 12 and 24h in group FM and FMH were significantly lower than those in group F and M (P＜0.05). There was no significant difference in the duration of mechanical ventilation, oxygen therapy time, hospital stay, adequate enteral feeding time and short-term side effects among the four groups. Conclusion Fentanyl combined with midazolam in mechanical ventilation of premature infants can effectively relieve pain, reduce RR, and reduce the occurrence of human-machine confrontation. However, the optimal dosage of fentanyl combined with midazolam remains to be further studied. |
| keywords:fentanyl midazolam premature infant analgesia mechanical ventilation |
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