| Research progress of microfluidic chip technology in sperm optimization |
| Received:May 11, 2022 Revised:December 05, 2022 Click here to download the full text |
| Citation of this paper:LU Xin-mei,DONG Xi,LIU Su-ying,SHI Hui-juan.Research progress of microfluidic chip technology in sperm optimization[J].Chinese Journal of Clinical Medicine,2023,30(6):1061-1066 |
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| Author Name | Affiliation | E-mail | | LU Xin-mei | Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute for Biomedical and Pharmaceutical Technologies, NHC Key Lab of Reproduction Regulation, Shanghai 200237, China
Pharmacy School, Fudan University, Shanghai 200032, China | | | DONG Xi | Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIU Su-ying | Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHI Hui-juan | Shanghai Institute for Biomedical and Pharmaceutical Technologies, NHC Key Lab of Reproduction Regulation, Shanghai 200237, China
Pharmacy School, Fudan University, Shanghai 200032, China | shihuijuan2011@163.com |
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| Abstract:Sperm optimization is the key to in vitro fertilization (IVF) and is extremely important to improve the success rate of assisted reproductive technology (ART). Studies have confirmed that steps such as centrifugation in routine semen processing methods may lead to higher levels of reactive oxygen species (ROS) and damage sperm DNA. In the natural state, sperm needs to overcome a series of anatomical barriers in the female reproductive tract and migrates through "microchannels" formed by mucus. The microfluidic chip, characterized by miniaturization and automation, can simulate the process of natural selection in the female reproductive tract, and optimally obtain high-quality sperm from the original semen, which is important for improving IVF efficiency and improving pregnancy outcome. This review focuses on the recent advances in sperm optimization implemented in microfluidic chips and provides an outlook of its clinical application. |
| keywords:microfluidic chip sperm quality sperm optimization DNA fragmentation in vitro fertilization |
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