| The progress in the diagnosis of transthyretin cardiac amyloidosis |
| Received:March 13, 2022 Revised:August 11, 2022 Click here to download the full text |
| Citation of this paper:MENG Fang-min,ZHOU Nian-wei,PAN Cui-zhen.The progress in the diagnosis of transthyretin cardiac amyloidosis[J].Chinese Journal of Clinical Medicine,2023,30(3):534-540 |
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| Author Name | Affiliation | E-mail | | MENG Fang-min | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHOU Nian-wei | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | PAN Cui-zhen | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai 200032, China | pan.cuizhen@zs-hospital.sh.cn |
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| Abstract:Transthyretin cardiac amyloidosis (ATTR-CA) is a restrictive cardiomyopathy in which transthyretin is deposited in the myocardial interstitium, resulting in heart failure, atrial fibrillation, and conduction block. Its clinical manifestations are diverse and non-specific, and misdiagnosis and missed diagnosis often occurr. With the development of relevant research and technology, multimodality imaging techniques such as electrocardiogram, echocardiography, cardiac magnetic resonance, radionuclide imaging could provide more valid information for its diagnosis. Genetic testing is clinically used to distinguish its subtypes. Although the overall prognosis of the disease is poor, with the continuous research on its pathogenesis, effective treatment methods have been developed and the therapeutic efficacy is getting better and better. Early recognition and diagnosis were essential for treatment of the disease. This review focused on the latest advances in diagnosis of ATTR-CA. |
| keywords:cardiac amyloidosis transthyretin cardiac amyloidosis echocardiography genetic test |
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