| Effects of hydroxychloroquine used in early time on the chest imaging changes of coronavirus disease 2019 (COVID-19) patients |
| Received:January 17, 2022 Revised:April 08, 2022 Click here to download the full text |
| Citation of this paper:SU Yi,LING Yun,MA Yu-yan,ZHANG Yao,PAN Jue,LU Hong-zhou,HU Bi-jie.Effects of hydroxychloroquine used in early time on the chest imaging changes of coronavirus disease 2019 (COVID-19) patients[J].Chinese Journal of Clinical Medicine,2022,29(2):129-133 |
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| Author Name | Affiliation | E-mail | | SU Yi | Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LING Yun | Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai 201058, China | | | MA Yu-yan | Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Yao | Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | PAN Jue | Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LU Hong-zhou | Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai 201058, China | | | HU Bi-jie | Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China | hu.bijie@zs-hospital.sh.cn |
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| Abstract:Objective To analyze the efficacy of multiple treatments including hydroxychloroquine used in early time on the chest imaging changes of coronavirus disease 2019 (COVID-19) patients. Methods Clinical data including general information, clinical performance, lab indexes, imaging performance, treatment schemes, and prognosis were retrospectively collected. Binary logistic regression was used to screen the factors associated with advances in chest imaging, and Cox proportional hazards model was used to estimate the effects of prognostic factors on the improvement time in chest imaging. Kaplan-Meier curves were used to analyze the effect of hydroxychloroquine used early on imaging prognosis of patients. Results A total of 498 non-light patients were selected, including 48 (86.35%) common patients, 50 (10.04%) severe patients, and 18 (3.61%) critical patients, with a median age of 43 (32,59) years. Among them, 176 (35.34%) patients were treated with hydroxychloroquine. The early use of hydroxychloroquine was a favorable factor for the imaging improvement (95% CI 0.517-0.870，P＝0.003). The median time to imaging improvement was 7 d in the hydroxychloroquine used early group, which was 9 d in the without hydroxychloroquine used group (P＜0.001). Conclusion Early use of hydroxychloroquine could improve chest imaging changes of patients with COVID-19. |
| keywords:coronavrius disease 2019 (COVID-19) hydroxychloroquine treatment imaging |
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