| Correlation of depression and anxiety and cognitive function in elderly patients with cognitive impairment |
| Received:January 08, 2022 Revised:February 13, 2022 Click here to download the full text |
| Citation of this paper:WANG Jin-xiu,WANG Jian-tao,HU Yue,WANG Xin-ru,REN Jiao-qi,WANG Yin,ZHANG Yu-tu,ZHOU Hou-guang.Correlation of depression and anxiety and cognitive function in elderly patients with cognitive impairment[J].Chinese Journal of Clinical Medicine,2022,29(4):536-543 |
| Hits: 1504 |
| Download times: 471 |
| Author Name | Affiliation | E-mail | | WANG Jin-xiu | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | WANG Jian-tao | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | HU Yue | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | WANG Xin-ru | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | REN Jiao-qi | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | WANG Yin | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | ZHANG Yu-tu | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | | | ZHOU Hou-guang | Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China | zhg7376@163.com |
|
| Abstract:Objective To explore the clinical significance of depression and anxiety assessment in elderly patients with cognitive impairment, and to analyze the possible influencing factors of cognitive decline in the elderly. Methods A total of 242 patients suspected cognitive impairment were screened in the Department of Geriatrics, Huashan Hospital, Fudan University, from June 2019 to November 2021, included 37, 62, and 143 patients in the non-cognitive impairment, mild cognitive impairment (MCI), and dementia groups, respectively. Cognition level (MMSE+MoCA) and depression and anxiety score (PHQ-9+GAD-7) were assessed. The biochemical indexes related to cognition such as thyroid function, syphilis and human immunodeficiency virus serum markers, homocysteine, folic acid, vitamin B12, autoimmune encephalitis antibody, Alzheimer-associated neurofilament protein (AD7c-NTP) were examined. Results There were 12(32.4%), 30 (48.4%), and 82(57.3%) depression patients, and 10(27.0%), 24(38.7%), and 72(50.3%) anxiety patients in the non-cognitive impairment group, MCI group, and dementia group, respectively. The differences of depression and patients rates were statistically significant between the MCI and dementia groups (P<0.05). No significant difference was observed in thyroid function, autoimmune encephalitis level among the three groups. There were significant differences in the abnormal rates of HCY, folate, and AD7c-NTP (P<0.05), rather than vitamin B12. Disorderly multi-category logistic regression analysis showed that increased age and GAD-7 score were risk factors of MCI, and increased Age, HCY, PHQ-9 and GAD-7 scores were risk factors of dementia, using the non-cognitive impairment group as reference; GAD-7 score was risk factor of dementia using MCI group as reference. Conclusions The elderly patients with cognitive impairment were prone to depression and anxiety, and cognitive function may be correlated with depression and anxiety, age, HCY and folic acid levels. It is necessary to assess depression and anxiety in outpatient patients with suspected cognitive impairment. |
| keywords:cognitive impairment depression anxiety influencing factors the elderly |
| HTML View Full Text View/Add Comment Download reader |
|
|
|