| Mechanisms of anti-aging effects of Apocynum venetum L. |
| Received:December 28, 2021 Revised:May 27, 2022 Click here to download the full text |
| Citation of this paper:WANG Fei,LI Xiang-ting,XU Li-li,ZHANG Ya-zhen,XIANG Jun.Mechanisms of anti-aging effects of Apocynum venetum L.[J].Chinese Journal of Clinical Medicine,2022,29(4):596-602 |
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| Author Name | Affiliation | E-mail | | WANG Fei | Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LI Xiang-ting | Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | XU Li-li | Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Ya-zhen | Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | XIANG Jun | Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Institute of Internal Medicine, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China | xiang.jun@zs-hospital.sh.cn |
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| Abstract:Objective To explore mechanisms of the anti-aging effects of A.pocynum venetum L.. Methods The anti-aging related components, targets, molecular function and pathway of A. venetum were obtained by network pharmacology. The anti-aging effect and key target of A. venetum were verified using the aging mouse model. Results 9 active components, 85 key targets, 116 molecular functions and 163 pathways of A. venetum were obtained. A. venetum protected mouse against D-galactose induced aging, and down-regulated expression of p53. Conclusions A. venetum, has multiple active components, could protect against aging by down-regulating expression of p53. |
| keywords:Apocynum venetum L. anti-aging effect mechanism |
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