| The analysis on the safe interval length between two-stage resections for bilateral multiple primary lung cancer |
| Received:December 06, 2021 Revised:March 03, 2022 Click here to download the full text |
| Citation of this paper:XU Feng-kai,WANG Lin,LU Chun-lai,GU Jie,ZHU Qiao-liang,YANG Hui-qin,CHENG Tao,LIN Zong-wu,GE Di.The analysis on the safe interval length between two-stage resections for bilateral multiple primary lung cancer[J].Chinese Journal of Clinical Medicine,2022,29(3):454-458 |
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| Author Name | Affiliation | E-mail | | XU Feng-kai | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Lin | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LU Chun-lai | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GU Jie | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHU Qiao-liang | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | YANG Hui-qin | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHENG Tao | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIN Zong-wu | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | GE Di | Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China | ge.di@zs-hospital.sh.cn |
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| Abstract:Objective To explore the optimal interval length between two-stage surgery, based on the reduction of pulmonary function after the first operation and the safety of follow-up of the lesion. Methods A total of 121 patients with simultaneous bilateral multiple primary lung cancers were retrospectively enrolled, who underwent two-stage resection in one year from 2008 to 2019 in Zhongshan Hospital, Fudan University. According to the interval length between the two-stage surgery, patients were distributed into short-term (≤ 6 months) and long-term (6-12 months) groups. Changes in preoperative pulmonary function (forced expiratory volume in the first second) and lesion features (size and solid component) between two-stage operation were compared between 2 groups. Results The reduction degree of FEV1 in the short-term group was higher than that in the long-term group ([0.36±0.25] L vs[0.26±0.24] L, P=0.047). There was no significant difference in postoperative complications after the first-stage operation (11.1% vs 12.2%) and the two-stage operation (8.3% vs 0) between the two groups. The progress rate of lesion in the long-term group was higher than that in the short-term group. The progression rates of ground glass nodules (21.1% vs 0), sub-solid nodules (47.6% vs 6.5%) and solid nodules (67.0% vs 16.7%) in the long-term group were higher than those in the short-term group (P<0.05). During the follow-up time, the incidence of progression occurred had elevating trand, with solid components in the lesion increased. Conclusion The interval length of 6-12 months between two-stage operation is relatively safe for the pulmonary function, and when lesion is solid, the interval should be as short as possible, even underwent one-stage resection under ensuring surgical safety. |
| keywords:bilateral multiple primary lung cancer pulmonary function two-stage operation interval length safty |
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