| The prognostic value of serum FT3/FT4 ratio in chronic kidney disease patients with crescent formation |
| Received:November 03, 2021 Revised:February 21, 2022 Click here to download the full text |
| Citation of this paper:ZHANG Li-wen,WU Yu-xiao,NIE Yu-xin,Lü Wen-lü,ZHU Bo-wen,JIN Shi,SHEN Zi-yan,LI Fang,LIU Hong,FANG Yi,DING Xiao-qiang.The prognostic value of serum FT3/FT4 ratio in chronic kidney disease patients with crescent formation[J].Chinese Journal of Clinical Medicine,2022,29(3):354-359 |
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| Author Name | Affiliation | E-mail | | ZHANG Li-wen | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | WU Yu-xiao | Department of Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | NIE Yu-xin | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | Lü Wen-lü | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | ZHU Bo-wen | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | JIN Shi | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | SHEN Zi-yan | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | LI Fang | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | LIU Hong | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | | | FANG Yi | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | fang.yi@zs-hospital.sh.cn | | DING Xiao-qiang | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Institute of Kidney and Dialysis, Shanghai Medical Center of Kidney, Shanghai Key Laboratory of Kidney and Blood Purification, Hemodialysis Quality Control Center of Shanghai, Shanghai 200032, China | |
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| Abstract:Objective To explore the association between FT3/FT4 ratio and renal function in chronic kidney disease (CKD) patients with crescent formation and its prognostic value. Methods Clinical data of 119 CKD patients with crescent formation confirmed by kidney biopsy in the Department of Nephrology, Zhongshan Hospital, Fudan University from March 2012 to May 2014 were retrospectively analyzed. The differences in clinical characteristics and laboratory tests were compared between the two groups. Cox regression analysis was used to analyze the risk factors of the composite endpoint of a 50% decrease in estimated glomerular filtration rate (eGFR) plus the initiation of renal replacement therapy or death. Results There were significant differences in gender, age, proportion with hypertension, urine albumin-creatinine ratio, 24-hour urine protein, eGFR, serum albumin, thyroid function, renal pathology, and medicine treatments between the two groups (P<0.05). The multivariate Cox regression showed that hypertension and elevated cTnT were independent risk factors for the composite endpoint (P<0.05). Compared to patients in the high-level FT3/FT4 ratio group, composite endpoint risk of patients in the low-level group was higher (P<0.01). After adjusting for the effect of pathological type, degree of renal tubular lesion or eGFR level, the risk of composite endpoint was still higher in patients with low FT3/FT4 ratio (P<0.05). Conclusion The FT3/FT4 ratio is probably a new prognostic factor for CKD patients with crescent formation, which may play an important role in the formulation and adjustment of treatment plans. |
| keywords:crescent formation chronic kidney disease FT3/FT4 ratio prognosis |
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