| Analysis of prognostic factors affecting long-term survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization |
| Received:November 01, 2021 Revised:May 12, 2022 Click here to download the full text |
| Citation of this paper:WANG Dong,ZHANG Wei,QIAN Sheng,ZHU Liang,ZHOU Bo,QU Xu-dong,YAN Zhi-ping,WANG Jian-hua,XU Li-gang,SUN Yue-jun,YANG Guo-wei,LIU Rong.Analysis of prognostic factors affecting long-term survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization[J].Chinese Journal of Clinical Medicine,2022,29(3):389-395 |
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| Author Name | Affiliation | E-mail | | WANG Dong | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZHANG Wei | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | QIAN Sheng | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZHU Liang | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | ZHOU Bo | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | QU Xu-dong | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | YAN Zhi-ping | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | WANG Jian-hua | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | XU Li-gang | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | SUN Yue-jun | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | | | YANG Guo-wei | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | yang.guowei@zs-hospital.sh.cn | | LIU Rong | Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China | liu.rong@zs-hospital.sh.cn |
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| Abstract:Objective To explore the prognostic factors that affect the long-term survival of hepatocellular carcinoma(HCC) patients after transcatheter arterial chemoembolization(TACE) treatment. Methods 258 patients with HCC treated in the Interventional Department of Zhongshan Hospital, Fudan University from January 2003 to June 2014 were collected. According to the survival time, they were divided into long-term survival group (survival time ≥ 5 years, n=150) and short-term survival group (survival time <5 years, n=108). All patients were treated with TACE initially. While, some patients received further combined therapy, such as surgical resection, molecular targeted drugs, and/or other interventional procedures. The clinical data of the two groups of patients were retrospectively compared and analyzed to explore factors affecting the long-term survival of patients after TACE treatment. Results The median survival time of patients was 97 months in long-term survival group (95%CI 84.5~109.5), and 14 months in short-term survival group (95%CI 10.4~17.6). Univariate analysis showed that the number of tumors, tumor size, tumor boundary, AFP value, tumor stage, arteriovenous/portal fistula, extrahepatic metastasis, and portal vein invasion/portal vein tumor thrombus, lipiodol deposition status, extrahepatic tumor arterial blood supply, tumor borders, and accessibility to combined therapy are statistically significant (P<0.05). Cox regression risk model showed that the number of tumors ≤ 3(HR=2.141, P<0.01), uninvaded portal vein/no portal vein tumor thrombus(HR=1.679, P=0.017), lipiodol deposition state Ⅰ+Ⅱ(HR=3.554, P<0.01), combined therapy(HR=2.745, P<0.01) are independent factors influencing the long-term survival of HCC patients with TACE treatment. Conclusion TACE and combined therapy based on TACE are safe and effective treatments for HCC patients. The quantity of tumors before TACE, the portal vein invasion/portal vein tumor thrombus, the state of lipiodol deposition after TACE, and combined therapy are all independent factors which affecting the long-term survival of HCC patients. |
| keywords:hepatocellular carcinoma transcatheter arterial chemoembolization combined modality therapy long-term survival influence factor |
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