| Effect of stroke volume variation guided fluid therapy on intestinal barrier function in patients undergoing radical gastrectomy |
| Received:October 12, 2021 Revised:January 28, 2022 Click here to download the full text |
| Citation of this paper:ZHANG Jian-you,MENG Yi-fan,HE Yan,CHEN Mao-gui,WANG Lin,ZHOU Ming.Effect of stroke volume variation guided fluid therapy on intestinal barrier function in patients undergoing radical gastrectomy[J].Chinese Journal of Clinical Medicine,2022,29(4):559-564 |
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| Author Name | Affiliation | E-mail | | ZHANG Jian-you | Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | | | MENG Yi-fan | Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | | | HE Yan | Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | | | CHEN Mao-gui | Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | | | WANG Lin | Department of Anesthesiology, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | | | ZHOU Ming | Department of General Surgery, the Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China | mingzhou@yzu.edu.cn |
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| Abstract:Objective To investigate the effect of stroke volume variation (SVV) guided fluid therapy on intestinal barrier function in patients undergoing laparoscopic radical gastrectomy. Methods 60 patients undergoing elective radical gastrectomy were randomly divided into two groups:group G (goal-directed fluid therapy group, n=30) and group C (classical fluid therapy group, n=30). Group G was given fluid replacement according to the guidance of SVV during operation. Group C was given fluid replacement according to the total amount of infusion (physiological requirement + cumulative loss + compensatory dilatation + loss of the third space + blood loss during operation) during operation. The mean arterial pressure (MAP), heart rate (HR), and cardiac index (CI) were monitored during operation and in recovery room. The concentrations of plasma intestinal fatty acid binding protein (I-FABP) and D-lactic acid were measured before anesthesia and within 3 days after operation. The first exhaust time, postoperative hospital stay, and the occurrence of postoperative adverse reactions were recorded. Results There was no significant difference in MAP, HR, and CI during operation between the two groups. The intraoperative crystalloid infusion volume, colloid infusion volume, and total infusion volume in group G were significantly less than those in group C (P<0.05). Three days after operation, the levels of D-lactic acid and I-FABP in group C were significantly higher than those in group G (P<0.01). The first exhaust time and hospital stay in group G were significantly shorter than those in group C (P<0.01). Conclusions Compared with traditional fluid replacement, SVV guided fluid therapy can reduce the amount of fluid infusion during laparoscopic radical gastrectomy in patients with gastric cancer, ensure good circulatory perfusion, better protect intestinal barrier function and reduce the length of stay of patients afer operation. |
| keywords:goal-directed fluid therapy stroke volume variation intestinal barrier function radical gastrectomy |
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