| Regulating effect of vitamin D on Th17/Treg cell imbalance in patients with Graves' disease |
| Received:September 17, 2021 Revised:May 09, 2022 Click here to download the full text |
| Citation of this paper:SHI Liang-feng,SU Yi-qian,WANG Chuan-jie.Regulating effect of vitamin D on Th17/Treg cell imbalance in patients with Graves' disease[J].Chinese Journal of Clinical Medicine,2022,29(3):426-430 |
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| Author Name | Affiliation | E-mail | | SHI Liang-feng | Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, China | | | SU Yi-qian | Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai 201508, China | | | WANG Chuan-jie | Department of Rehabilitation, Jinshan Hospital, Fudan University, Shanghai 201508, China | wajk2001@126.com |
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| Abstract:Objective To explore the regulating effect of vitamin D on Th17/Treg cell imbalance in patients with Graves' disease. Methods Thirty patients with GD and thirty healthy controls in Jinshan Hospital, Fudan University from January to December 2020 were collected.The levels of 25-OH vitamin D in the two groups were measured by electrochemiluminescence immunoassay.The peripheral blood of GD patients was divided into two parts on average as vitamin D non-intervention group and vitamin D intervention group.The percentages of Th17 and Treg cells and Th17/Treg ratio in peripheral blood in GD non-intervention group, GD intervention group and control group were compared. Results Serum 25-OH vitamin D ([20.55±6.69] ng/mL) in GD patients was significantly lower than that in healthy control group ([25.48±6.12] ng/mL, P=0.004).The percentage of Th17 cells in peripheral blood in GD non-intervention group, GD intervention group, and control group were (0.299±0.191)%, (0.263±0.176)%, (0.054±0.017)%, respectively. The percentages of Th17 cells in peripheral blood in two GD groups were significantly higher than that in the control group (P<0.001). There was no significant difference in the level of Th17 cells in peripheral blood between he two GD groups.The percentage of Treg cells in peripheral blood in the three groups were (0.029±0.013)%, (0.040±0.019)% and (0.037±0.017)%, respectively. There was no significant difference in the percentage of Treg cells in peripheral blood between the two GD groups and the control group. The percentage of Treg cells in GD intervention group was higher than that in GD non-intervention group (P=0.019). The Th17/Treg cell ratio in the three groups were 14.97±8.90, 8.08±5.37, 1.64±0.67, respectively. The ratio of Th17/Treg cells in peripheral blood in the two GD groups was significantly higher than that in the control group (P<0.001).The ratio of Th17/Treg cells in peripheral blood of GD intervention group was lower than that in the GD non- intervention group (P<0.001). Conclusions For initial GD patients, the serum vitamin D level is seriously deficient, Th17 cell in peripheral blood increases, and Th17/Treg cell is imbalance. Vitamin D plays an important role for up-regulating of Treg cells and regulating Th17/Treg cell imbalance in GD patients. |
| keywords:vitamin D Graves' disease Th17 cell Treg cell |
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