| Mechanism and strategy of regulatory T cells in pancreatic cancer immunotherapy |
| Received:August 01, 2021 Revised:November 02, 2021 Click here to download the full text |
| Citation of this paper:LEI Yang-yang,LI Jian-ke,WANG Xiao-lin,LI Guo-ping.Mechanism and strategy of regulatory T cells in pancreatic cancer immunotherapy[J].Chinese Journal of Clinical Medicine,2022,29(6):1046-1051 |
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| Author Name | Affiliation | E-mail | | LEI Yang-yang | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Biliary and Pancreatic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510220, Guangdong, China | | | LI Jian-ke | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | WANG Xiao-lin | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LI Guo-ping | Shanghai Institute of Medical Imaging, Shanghai 200032, China
Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | gpli2001@163.com |
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| Abstract:Immunotherapy for pancreatic cancer is not effective in clinical trials, mainly because of its tumor microenvironment (TME) with high immunosuppression. Regulatory T cells (Tregs) are a subset of T cells that control the autoimmune response and are one of the main components of immunosuppressive TME. It was found that Tregs could regulate the immune response, inhibit the function and activity of effector T cells, thus inducing immune tolerance and maintaining immune homeostasis. In the TME of pancreatic cancer, Tregs could inhibit the immune response and induce the immune escape of tumor cells, which affect the prognosis and therapeutic effect of patients. This review summarizes the mechanism of Tregs in the immune microenvironment of pancreatic cancer and its clinical significance in order to provide new insights for the immunotherapy of pancreatic cancer. |
| keywords:regulatory T cell pancreatic cancer tumor microenvironment immunotherapy |
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