| Role of microRNA-34 cluster and its therapeutic potential: a review of the literature |
| Received:July 29, 2021 Revised:September 14, 2021 Click here to download the full text |
| Citation of this paper:WU Jia-wei,YU Shao-zheng.Role of microRNA-34 cluster and its therapeutic potential: a review of the literature[J].Chinese Journal of Clinical Medicine,2022,29(5):875-884 |
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| Abstract:MicroRNA-34 (miR-34) cluster includes miR-34a, miR-34b and miR-34c, which are closely related to the normal development of human body and the maintenance of multiple organ functions. The expression of miR-34 is regulated by tumor suppressor gene p53 and long non-coding RNAs (lncRNAs). Its unbalanced expression will lead to the occurrence and development of a series of diseases. MiR-34 is closely related to tumorigenesis and development. It plays an anti-cancer role mainly by blocking cell cycle, inducing apoptosis and autophagy, inhibiting epithelial mesenchymal transformation, and preventing cell migration and invasion. There is new evidence that miR-34 also plays an important role in cardiac protection. The function of miR-34 mainly involves NF-κB, Notch and other signaling pathways. The regulation based on the expression of miR-34 is conducive to the control and prognosis of some diseases. miR-34 is a potential target for clinical diagnosis and treatment, and has broad clinical application prospects. Therefore, this paper reviews the function and application progress of miR-34 cluster to provide reference for follow-up research. |
| keywords:miR-34 cluster p53 lncRNA tumor inhibition cardiac protection signaling pathways |
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