| Expressions of serum IL-6, IL-25 and IL-31 in patients with psoriasis and their clinical significances |
| Received:July 18, 2021 Revised:February 27, 2022 Click here to download the full text |
| Citation of this paper:LIU Fang,PANG Xiao-wen,ZHANG Ping,LIU Wen,LIN Kai,ZHU Sai-nan.Expressions of serum IL-6, IL-25 and IL-31 in patients with psoriasis and their clinical significances[J].Chinese Journal of Clinical Medicine,2022,29(6):987-991 |
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| Author Name | Affiliation | E-mail | | LIU Fang | Department of Dermatology, Air Force Special Medical Center, PLA, Beijing 100142, China | | | PANG Xiao-wen | Department of Dermatology, Air Force Special Medical Center, PLA, Beijing 100142, China | pangxiaowen6712@163.com | | ZHANG Ping | Department of Dermatology, Air Force Special Medical Center, PLA, Beijing 100142, China | | | LIU Wen | Department of Dermatology, Air Force Special Medical Center, PLA, Beijing 100142, China | | | LIN Kai | Department of Clinical Laboratory, Air Force Special Medical Center, PLA, Beijing 100142, China | | | ZHU Sai-nan | Department of Medical Statistics, Peking University First Hospital, Beijing 100034, China | |
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| Abstract:Objective To explore the regulatory roles of IL-6,IL-25,IL-31 in immune inflammation of psoriasis. Methods From January 2013 to December 2014, 70 patients with psoriasis and 70 healthy people who received physical examination in the Department of Dermatological of the Air Force Special Medical Center, PLA were selected. The counts of neutrophils and lymphocytes in peripheral venous blood of 70 patients with psoriasis were determined by Sysmex XE-2100 automatic flow cytometry, and the ratio of neutrophils to lymphocytes (NLR) was calculated. The serum levels of IL-6, IL-25 and IL-31 in patients with psoriasis were detected by Luminex 200 liquid phase chip detection system and were compared with that in the healthy control group. Results NLR in patients with special psoriasis was significantly higher than that in patients with psoriasis vulgaris and the normal controls (P<0.01). NLR was highly positively correlated with psoriasis area and severity index (PASI, P<0.01). Serum levels of IL-6, IL-25 and IL-31 in patients with psoriasis were normal Serum level of IL-6 in patients with special psoriasis was higher than that in the normal controls and patients with psoriasis vulgaris (P<0.05), and was positively correlated with NLR (P<0.05). The serum levels of IL-25 and IL-31 in patients with special psoriasis decreased than those in patients with psoriasis vulgaris (P<0.05), which were negatively correlated with PASI (P<0.05) and NLR (P<0.01). Conclusions Psoriasis as a T cell mediated systemic immune inflammatory response, involves a variety of Th cells and related cytokines. NLR reflects the severity of systemic Immune inflammation in psoriasis, while Th2 cells may play a related regulatory role in Th immune migration in patients with psoriasis through IL-6, IL-25 and IL-31. |
| keywords:psoriasis interleukin cytokine immune inflammation |
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